I had my spleen removed two years ago. Folate, another B vitamin, and vitamin B-12 are both involved in some of the same chemical reactions required to make normal sized red blood cells. This is a nonspecific finding. Measurement of Alcohol-Dependent Physiological Changes in Red Blood Cells Using Resistive Pulse Sensing. CANCER: Excessive alcohol consumption is linked to an increase in the risk of most cancers. Specifically, alcohol affects bone marrow and suppresses the normal production of red blood cells (RBCs). What can happen iF your sodium levels are low and red blood cells are enlarged? Among the most common are vitamin B12 deficiency, folate deficiency, alcoholism, hypothyroidism (under-active thyroid) and liver disease. Top Searches Holiday Gifts. Blood makes up nearly 7 percent of the total body weight. Chronic, excessive consumption of alcohol can lead to abnormal structure of RBCs and the presence of macrocytes (enlarged RBCs), a condition known as macrocytosis. Answered by : Dr. Prashant ( Gastroenterologist) Suggest treatment for low sodium levels in blood . Can abstaining ... View answer. I would like to finally get to the bottom of why I am often so very tired that I feel as if I can hardly lift my arms, etc - going on 3 yrs. For example, symptoms of anemia in a person may lead to investigations of blood that uncover the presence of macrocytosis as well. I am in the process of having a coeliac disease test done (allergy to gluten) as my grandmother has this. Low folate levels and some drugs such as methotrexate, used to treat some cancers or rheumatic or immune conditions, interfere with folate metabolism and may cause the condition. 6 months ago. Excess red blood cells and platelets eventually can clog your spleen and affect normal functioning. Risk factors. Inflammation and nutrient deficiencies can reduce red blood cell numbers or their ability to effectively deliver oxygen. Answer (1 of 2): Enlarged red blood cells should not cause any health symptoms or problems. The primary function of the red blood cell is to transport oxygen to all parts of the body. Trending. ''Alcohol is a general toxin that will damage every cell … I was also once on monthly B12 injections for a year. I am always tired and feel sick after eating, have a sore mouth and itchy skin. The most common cause is drinking too much alcohol. I also have enlarged red blood cells, I quit drinking for 4 months and the test still came out low B12 and folic and the red blood cells are still enlarged. Red blood cells are mainly involved in carrying oxygen to different tissues and organs. It can be caused by a number of things, Liver disease, thyroid disease also vitamin b12 defiency. The enlarged erythrocytes are called macrocytes or megalocytes (both words have roots meaning "big cell"). Therefore further investigations are necessary to identify the cause, as some of these causative factors can be very serious in nature. Will take a look but I think the docs think it may be vitamin b12 with my sister although her red cells are enlarged and she has suddenly lost all this weight for no real reason. Blood is made up of three different types of cells namely red blood cells, white blood cells and platelets. An enlarged spleen may even outgrow its own blood supply, which can damage or destroy sections of the organ. The doctor (a different one) again talked about alcohol consumption and checked it again during another consultation. Enlarged spleen (splenomegaly) symptoms may include pain in the upper abdomen, indigestion, or hiccups. In addition to alcohol abuse, macrocytosis is observed in megaloblastic anemia, commonly caused by vitamin B 12 and folate deficiency. ... (2 replies) I'm seeing a doc very soon and want to be armed with all of what I should ask to treat my enlarged red blood cells, which was brought up by my doc's substitute on my last visit. Having large red blood cells is not dangerous. enlarged red blood cells and alcohol consumption: 4 results. Your doctor will order blood tests to check for anemia and enlarged red blood cells. Nutrient deficiency of either folate or vitamin B12 results in enlarged red blood cells (megaloblastic anemia), with an MCV increased to a range of 105 to 160 fl . People with enlarged red blood cells are normally unaware that they have this condition. MD. Thanks for this. Macrocytosis is the term for enlarged red blood cells. Alcoholism may create large red blood cells. Elements like sun exposure, rosacea, alcohol consumption, weather … It travels throughout the body via arteries and veins. I consume alcohol frequently and in considerable quantity. Macrocytic anemia is derived from the Greek meaning "large cell". By continuing to use this site you consent to the use of cookies on your device as described in our cookie policy unless you have disabled them. We use cookies to give you the best possible experience on our website. For the past few years, every time I've had blood work done, the results have indicated that I have large red blood cells.Last month, I had more blood work done and now not only do I have enlarged red blood cells but I have a larger than normal number of red blood cells. Macrocytosis or an increase in enlarged cells can be caused by the following: * Vitamin B12 and Folate defiency, causes a distorted mitosis. Macrocytosis is the enlargement of red blood cells with near-constant hemoglobin concentration, and is defined by a mean corpuscular volume (MCV) of greater than 100 femtolitres (the precise criterion varies between laboratories). Something to note but not get excited about. 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